Some abbreviations - Molecular composition of skeletal muscle in infants and adults:

11 October 2024 Articles ، Terminology ، Tobias Ruck ، Anne Schänzer ، Peter F M Van der Ven ، Rita Horvath Skeletal muscle research abbreviations ، Neuromuscular study terms ، Proteomics and transcriptomics ، DEP and DEG in muscle research ، GSEA in neuromuscular disease ، Label-Free Quantification in skeletal muscle ، Gene expression analysis in muscle ، Mitochondrial DNA and muscle function ، Principal Component Analysis in biology ، Overrepresentation Analysis in muscle studies

Key Abbreviations in Neuromuscular Disorders Research

The abbreviations listed below are directly related to the most recent article shared, which focuses on neuromuscular disorders and the molecular pathways involved. These terms help explain the key findings and methodologies discussed in the study.

DEP (Differential Expressed Protein): Proteins that show significant differences in their levels between two conditions, such as healthy versus diseased tissue.
DEG (Differential Expressed Gene): Genes that display different levels of activity between conditions, crucial for understanding disease progression.
DM (Deltoideus Muscle): A large muscle responsible for shoulder movement, often affected in neuromuscular disorders.
GM (Gastrocnemius Muscle): The main calf muscle essential for walking and standing.
GO (Gene Ontology): A system used to categorize and understand gene and protein functions in biological processes.
GSEA (Gene Set Enrichment Analysis): A method used to determine if a set of genes shows statistically significant differences between conditions.
IM (Intercostal Muscle): Muscles between the ribs that assist in breathing by expanding and contracting the ribcage.
LFQ (Label-Free Quantification): A proteomics technique that measures protein abundance without requiring chemical labeling.
mo (Month): A standard unit of time used in research timelines.
mtDNA-CN (Mitochondrial DNA Copy Number): Indicates mitochondrial function and cellular energy balance.
MS (Tandem Mass Spectrometry): An advanced method for identifying and measuring proteins in biological samples.
ORA (Overrepresentation Analysis): A statistical technique for identifying overrepresented biological pathways in gene or protein datasets.
PCA (Principal Component Analysis): A statistical tool for reducing data complexity while preserving key variations.
QFM (Quadriceps Femoris Muscle): The large thigh muscle essential for movement such as walking and running.