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Membrane Stabilization by Modified Steroid Offers a Potential Therapy for Muscular Dystrophy Due to
Personal take on this article: A potential therapy for a specific type of muscular dystrophy (LGMD2B), caused by mutations in the DYSF gene leading to reduced dysferlin protein levels, involves membrane stabilization. Dysferlin is crucial for repairing the membrane of healthy muscle fibers, and its deficit results in chronic muscle inflammation. In this study, the researchers compared the effects of two steroids, prednisolone and vamorolone (VBP15), on repairing dysferlin-deficient muscle …
