Clicky

Identification of the Wnt signal peptide that directs secretion on extracellular vesicles

14 December 24 Articles ، Michael A. Rudnicki ، Ehsan Javandoost ، Rashmi Kothary Wnt7a extracellular vesicle secretion ، Exosome-Binding Peptide (EBP) function ، Wnt signaling and muscle regeneration ، Coatomer proteins in EV secretion ، Duchenne muscular dystrophy Wnt7a therapy ، Long-range Wnt protein signaling ، EV-based drug delivery systems ، Noncanonical protein secretion pathways
Identification of the Wnt signal peptide that directs secretion on extracellular vesicles
This study identifies Exosome-Binding Peptide (EBP) as a key Wnt7a secretion signal for extracellular vesicles (EVs), enabling long-range intercellular signaling. EBP binds to coatomer proteins (COPA & COPB2), anchoring Wnt7a to EVs and enhancing muscle repair. This mechanism, conserved in Wnt proteins, has implications for neuromuscular disease therapies, including Duchenne muscular dystrophy (DMD). EBP-guided EV delivery could revolutionize targeted drug and protein therapies, bypassing traditional systemic delivery challenges.
more

REST/NRSF preserves muscle stem cell identity and survival by repressing alternate cell fates

11 August 24 Articles ، Michael A. Rudnicki ، Vahab Soleimani ، Guillaume Bourque ، Arezu Jahani-Asl ، Yasuhiro Yamada ، Tony Kwan REST/NRSF and muscle stem cells ، Regulation of muscle stem cell fate ، Epigenetic control in muscle regeneration ، Stem cell identity and REST function ، REST deletion and muscle atrophy ، Apoptosis in muscle stem cells ، Regenerative capacity of MuSCs
REST/NRSF preserves muscle stem cell identity and survival by repressing alternate cell fates
This study explores the role of REST/NRSF in preserving muscle stem cell identity by repressing non-muscle genes, ensuring proper regeneration and self-renewal.
more

Wnt7a is Required for Regeneration of Dystrophic Skeletal Muscle

20 March 24 Articles ، Michael A. Rudnicki ، Ehsan Javandoost Wnt7a and muscle regeneration ، Duchenne muscular dystrophy therapy ، Muscle repair mechanisms in DMD ، Wnt7a injection for muscle healing ، Skeletal muscle recovery factors ، Stem cell activation in muscle repair ، Therapeutic potential of Wnt7a
Wnt7a is Required for Regeneration of Dystrophic Skeletal Muscle
This study examines the role of Wnt7a in muscle regeneration, highlighting its necessity for muscle repair and its potential as a therapy for Duchenne muscular dystrophy.
more

Isolation of small extracellular vesicles from regenerating muscle tissue using Tangential Flow Filt

19 March 24 Articles ، Michael A. Rudnicki Extracellular vesicle isolation ، Muscle tissue EV purification ، Tangential Flow Filtration (TFF) for EVs ، Size Exclusion Chromatography (SEC) method ، Wnt7a and extracellular vesicles ، Muscle injury and EV release ، Bioactive vesicles in muscle regeneration
Isolation of small extracellular vesicles from regenerating muscle tissue using Tangential Flow Filt
This study presents an optimized protocol for isolating extracellular vesicles (EVs) from regenerating muscle tissue using TFF and SEC, ensuring purity and efficiency.
more

Recent Posts

Categories

I'd be delighted if you could explore the other sections of my website.

Biochemist Researcher . YouTuber . Medical Laboratory Tech

!I am Ali Nik Akhtar

Personal Website​​​​​​​

If you have any questions or would like to discuss further, please feel free to email me. I would be delighted to get to know you better.

Ready to start a collaboration...​​​​​​​

Contact Me

Nikakhtar422@gmail.com

All rights reserved. This website belongs to Ali Nik Akhtar.