This study identifies Exosome-Binding Peptide (EBP) as a key Wnt7a secretion signal for extracellular vesicles (EVs), enabling long-range intercellular signaling. EBP binds to coatomer proteins (COPA & COPB2), anchoring Wnt7a to EVs and enhancing muscle repair. This mechanism, conserved in Wnt proteins, has implications for neuromuscular disease therapies, including Duchenne muscular dystrophy (DMD). EBP-guided EV delivery could revolutionize targeted drug and protein therapies, bypassing traditional systemic delivery challenges.

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