The abbreviations listed below are directly related to the most recent article I shared, which focuses on neuromuscular disorders and the molecular pathways involved. These terms help explain the key findings and methodologies discussed in the study.   DEP (Differential Expressed Protein):   This refers to proteins that show significant differences in their levels between two conditions, such as healthy versus diseased tissue. Studying these proteins helps scientists understand the …

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This paper investigates the molecular differences between infant and adult skeletal muscles using proteomic and transcriptomic approaches. Researchers collected muscle biopsies from infants (aged 4-28 months) and adults (aged 19-65 years) to identify age-related changes. The study found significant differences in the expression of genes and proteins responsible for muscle structure, metabolism, and immune responses between these two groups. In infants, muscle fibers are less mature, and processes related to …

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Personal take on this article: This study explores the potential of Thrombospondin-4 (TSP4) as a cerebrospinal fluid (CSF) biomarker for monitoring therapy response in pediatric patients with Spinal Muscular Atrophy (SMA). SMA is a severe childhood neurodegenerative disease characterized by the loss of motor neurons, leading to muscle weakness and atrophy. Currently, there is a lack of reliable biomarkers that can indicate treatment response in SMA. Researchers conducted proteomic analyses …

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