This study investigates the critical role of the Repressor Element 1-Silencing Transcription Factor (REST), also known as Neuron-Restrictive Silencer Factor (NRSF), in maintaining the identity and function of muscle stem cells (MuSCs). MuSCs are responsible for the lifelong regeneration of skeletal muscle, and their proper function depends on the repression of non-muscle lineage genes. REST plays a key role in this process by actively silencing these genes, preventing …

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