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MitoNEET preserves muscle insulin sensitivity during ironoverload by regulating mitochondrial iron, reactive oxygenspecies and fission
Personal take on this article: MitoNEET, a mitochondrial protein, plays a protective role against insulin resistance in muscle cells during iron overload (IO). IO typically leads to an accumulation of iron in mitochondria, which in turn increases reactive oxygen species (ROS) and triggers excessive mitochondrial fission—both of which contribute to insulin resistance. By overexpressing MitoNEET, researchers observed a reduction in mitochondrial iron levels, decreased ROS production, and …
