Wnt proteins are essential for tissue regeneration and intercellular signaling. This study focuses on Wnt7a, a protein secreted via extracellular vesicles (EVs) during muscle repair. Unlike traditional pathways, Wnt7a utilizes a unique mechanism involving a specific 18-amino acid sequence called the Exosome-Binding Peptide (EBP). EBP directs Wnt7a to EVs by binding to coatomer proteins (COPA and COPB2), which anchor the protein to the EV surface, enabling its bioactivity in long-range …

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  Personal take on this article:   The injection of Wnt7a into muscles has been shown to speed up muscle repair and improve muscle health in a mouse model of Duchenne muscular dystrophy (DMD). However, it's not clear if Wnt7a is necessary for muscle repair. In this study, we looked at mice with and without Wnt7a in their muscles to see how well their muscles could heal after injury. We …

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