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Identification of the Wnt signal peptide that directs secretion on extracellular vesicles

14 December 24 Articles ، Michael A. Rudnicki ، Ehsan Javandoost ، Rashmi Kothary Wnt7a extracellular vesicle secretion ، Exosome-Binding Peptide (EBP) function ، Wnt signaling and muscle regeneration ، Coatomer proteins in EV secretion ، Duchenne muscular dystrophy Wnt7a therapy ، Long-range Wnt protein signaling ، EV-based drug delivery systems ، Noncanonical protein secretion pathways
Identification of the Wnt signal peptide that directs secretion on extracellular vesicles
This study identifies Exosome-Binding Peptide (EBP) as a key Wnt7a secretion signal for extracellular vesicles (EVs), enabling long-range intercellular signaling. EBP binds to coatomer proteins (COPA & COPB2), anchoring Wnt7a to EVs and enhancing muscle repair. This mechanism, conserved in Wnt proteins, has implications for neuromuscular disease therapies, including Duchenne muscular dystrophy (DMD). EBP-guided EV delivery could revolutionize targeted drug and protein therapies, bypassing traditional systemic delivery challenges.
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Wnt7a is Required for Regeneration of Dystrophic Skeletal Muscle

20 March 24 Articles ، Michael A. Rudnicki ، Ehsan Javandoost Wnt7a and muscle regeneration ، Duchenne muscular dystrophy therapy ، Muscle repair mechanisms in DMD ، Wnt7a injection for muscle healing ، Skeletal muscle recovery factors ، Stem cell activation in muscle repair ، Therapeutic potential of Wnt7a
Wnt7a is Required for Regeneration of Dystrophic Skeletal Muscle
This study examines the role of Wnt7a in muscle regeneration, highlighting its necessity for muscle repair and its potential as a therapy for Duchenne muscular dystrophy.
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