Immortalized Skeletal Muscle Cells: Advancing DMD Research

Introduction

Immortalized skeletal muscle cells derived from both healthy individuals and Duchenne muscular dystrophy (DMD) patients offer a powerful platform for scientific discovery in neuromuscular disorders. These cells provide a reproducible model for studying disease mechanisms and investigating therapeutic strategies, particularly in the context of exon-skipping therapies.

Role in Research & Therapy Development

By using these immortalized cells, researchers can explore how genetic mutations affect muscle cell function and assess the efficacy of therapeutic interventions designed to restore dystrophin expression. This model plays a pivotal role in preclinical research, supporting the development of innovative treatments aimed at improving the quality of life for individuals affected by DMD.

Scientific Contributions: Kamel Mamchaoui

A notable contribution to the development of immortalized myoblast cell lines has been made by Kamel Mamchaoui, who derived immortalized myoblasts from DMD patients at the Human Cell Immortalization Platform, Myology Center of Research. His expertise in creating human myoblast cell lines has significantly enhanced the tools available for investigating the biology of neuromuscular diseases, including muscular dystrophy.

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