This study focuses on translating microarray findings from golden retriever muscular dystrophy (GRMD) to identify biomarkers that could reflect cardiac and skeletal muscle function in Duchenne muscular dystrophy (DMD) patients. Since DMD affects both cardiac and skeletal muscle function, identifying molecular differences between these tissues can help predict disease progression. The research utilized GRMD models, which closely mimic DMD in humans, and studied gene expression in the left ventricle (LV) …

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Golden Retriever Muscular Dystrophy (GRMD) is a genetic disorder in dogs that closely resembles Duchenne Muscular Dystrophy (DMD) in humans. It is caused by a mutation in the *dystrophin* gene, which leads to the absence or severe deficiency of dystrophin protein in muscle cells. Without dystrophin, muscle cells become damaged and progressively weaken, leading to the characteristic symptoms of the disease. GRMD has been extensively studied as a model for …

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