Myotonic Dystrophy (DM) is an inherited, multisystemic disorder that affects muscle and various other organs. There are two types: DM1 and DM2. DM1, caused by CTG repeat expansion in the "DMPK" gene, is more common and severe, involving muscle weakness, myotonia, and systemic complications such as cardiac, respiratory, and gastrointestinal issues. DM2, caused by CCTG repeat expansion in the "CNBP" gene, presents with less severe systemic symptoms but is still …

more

Myotonic Dystrophy (DM) is a genetic disorder that affects muscle function and other systems of the body. There are two main types: 1. Myotonic Dystrophy Type 1 (DM1): Also known as Steinert's disease, DM1 is caused by a mutation in the "DMPK gene" (Dystrophia Myotonica Protein Kinase). The mutation involves an expansion of CTG trinucleotide repeats in this gene, leading to symptoms such as prolonged muscle contractions (myotonia), muscle weakness, …

more