Wnt proteins are essential for tissue regeneration and intercellular signaling. This study focuses on Wnt7a, a protein secreted via extracellular vesicles (EVs) during muscle repair. Unlike traditional pathways, Wnt7a utilizes a unique mechanism involving a specific 18-amino acid sequence called the Exosome-Binding Peptide (EBP). EBP directs Wnt7a to EVs by binding to coatomer proteins (COPA and COPB2), which anchor the protein to the EV surface, enabling its bioactivity in long-range …

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