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Identifying hub genes and dysregulated pathways in Duchenne muscular dystrophy

19 May 24 Articles Hub genes in Duchenne dystrophy ، DMD dysregulated pathways ، Differentially expressed genes in DMD ، Protein-protein interaction network analysis ، Molecular mechanisms of DMD progression ، Gene expression studies in muscular dystrophy ، Therapeutic targets for Duchenne dystrophy
Identifying hub genes and dysregulated pathways in Duchenne muscular dystrophy
This research explores differentially expressed genes (DEGs) and hub genes in Duchenne muscular dystrophy, analyzing their role in disease progression and treatment targets.
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Moving towards successful exon-skipping therapy for Duchenne muscular dystrophy

17 May 24 Articles ، Akinori Nakamura Exon skipping therapy for DMD ، Dystrophin restoration in Duchenne dystrophy ، Antisense oligonucleotide therapy ، Gene therapy for muscular dystrophy ، PMOs and 2’OMeAO for exon skipping ، Multi-exon skipping strategies ، Clinical trials for Duchenne dystrophy treatments
Moving towards successful exon-skipping therapy for Duchenne muscular dystrophy
This review explores exon skipping therapy for Duchenne muscular dystrophy, discussing preclinical and clinical trials, therapeutic challenges, and future developments.
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The Dysferlinopathies Conundrum: Clinical Spectra, Disease Mechanism and Genetic Approaches for Treatments

15 May 24 Articles ، Toshifumi Yokota Dysferlinopathies clinical features ، DYSF gene mutations and muscle weakness ، Muscle membrane repair disorders ، Genetic therapies for dysferlinopathies ، Pharmacological treatments for DYSF-related diseases ، Precision medicine in muscular dystrophies ، Animal models for dysferlinopathy research
The Dysferlinopathies Conundrum: Clinical Spectra, Disease Mechanism and Genetic Approaches for Treatments
This review examines dysferlinopathies, highlighting clinical features, molecular mechanisms, genetic therapies, and the latest research in treatment development.
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Duchenne muscular dystrophy: promising early-stage clinical trials to watch

21 March 24 Articles ، Toshifumi Yokota Duchenne muscular dystrophy clinical trials ، Early-stage DMD treatments ، Exon-skipping therapies for DMD ، Gene therapy for Duchenne dystrophy ، Micro-dystrophin gene therapy ، AON treatments for DMD ، New drugs for Duchenne muscular dystrophy
Duchenne muscular dystrophy: promising early-stage clinical trials to watch
This review highlights early-stage clinical trials for Duchenne muscular dystrophy, covering exon-skipping therapies, gene therapy, and novel treatment strategies.
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Wnt7a is Required for Regeneration of Dystrophic Skeletal Muscle

20 March 24 Articles ، Michael A. Rudnicki ، Ehsan Javandoost Wnt7a and muscle regeneration ، Duchenne muscular dystrophy therapy ، Muscle repair mechanisms in DMD ، Wnt7a injection for muscle healing ، Skeletal muscle recovery factors ، Stem cell activation in muscle repair ، Therapeutic potential of Wnt7a
Wnt7a is Required for Regeneration of Dystrophic Skeletal Muscle
This study examines the role of Wnt7a in muscle regeneration, highlighting its necessity for muscle repair and its potential as a therapy for Duchenne muscular dystrophy.
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Isolation of small extracellular vesicles from regenerating muscle tissue using Tangential Flow Filt

19 March 24 Articles ، Michael A. Rudnicki Extracellular vesicle isolation ، Muscle tissue EV purification ، Tangential Flow Filtration (TFF) for EVs ، Size Exclusion Chromatography (SEC) method ، Wnt7a and extracellular vesicles ، Muscle injury and EV release ، Bioactive vesicles in muscle regeneration
Isolation of small extracellular vesicles from regenerating muscle tissue using Tangential Flow Filt
This study presents an optimized protocol for isolating extracellular vesicles (EVs) from regenerating muscle tissue using TFF and SEC, ensuring purity and efficiency.
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Satellite Cell Heterogeneity in Skeletal Muscle Homeostasis

18 March 24 Articles ، Alessandra Sacco Satellite cell heterogeneity ، Skeletal muscle homeostasis ، Muscle stem cell differentiation ، Self-renewal in satellite cells ، Muscle regeneration mechanisms ، Stem cell fate in muscle repair ، Skeletal muscle stem cell diversity
Satellite Cell Heterogeneity in Skeletal Muscle Homeostasis
This article explores the role of satellite cell heterogeneity in skeletal muscle homeostasis, highlighting its impact on muscle repair, self-renewal, and differentiation.
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Vamorolone improves Becker muscular dystrophy and increases dystrophin protein in bmx model mice

25 June 23 Articles ، Alyson Fiorillo Vamorolone treatment for BMD ، Becker muscular dystrophy therapy ، Dystrophin protein increase ، BMX mouse model research ، Anti-inflammatory drugs for muscular dystrophy ، Inflamma-miRs in muscle diseases ، NF-kB and dystrophin regulation ، DMD and BMD comparative studies
Vamorolone improves Becker muscular dystrophy and increases dystrophin protein in bmx model mice
This study highlights vamorolone’s ability to improve Becker muscular dystrophy by reducing inflammation and increasing dystrophin levels in BMX model mice.
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The X-linked Becker muscular dystrophy (bmx) mouse models Becker muscular dystrophy via deletion of

10 January 23 Articles ، Alyson Fiorillo Becker muscular dystrophy (BMD) ، BMX mouse model ، Dystrophin gene mutation ، Muscle degeneration in BMD ، Heart complications in muscular dystrophy ، Animal models for neuromuscular diseases ، Preclinical trials for BMD ، Muscle repair and regeneration in BMD
The X-linked Becker muscular dystrophy (bmx) mouse models Becker muscular dystrophy via deletion of
This study introduces the BMX mouse model for Becker muscular dystrophy, providing a new tool for studying disease mechanisms and testing potential therapies.
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Interrogation of Dystrophin and Dystroglycan Complex Protein Turnover After Exon Skipping Therapy

30 September 21 Articles ، Alyson Fiorillo ، Terry Partridge ، Davi Mazala ، Kristy Brown ، Yetrib Hathout ، Kanneboyina Nagaraju ، Utkarsh J. Dang Dystrophin turnover ، Dystroglycan stability ، Exon skipping therapy ، Duchenne Muscular Dystrophy (DMD) ، Mass spectrometry in DMD ، Restored dystrophin stability ، Gene correction strategies DMD
Interrogation of Dystrophin and Dystroglycan Complex Protein Turnover After Exon Skipping Therapy
This study examines dystrophin and dystroglycan protein turnover after exon skipping therapy in DMD, highlighting protein stability changes and implications for gene correction strategies.
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Membrane Stabilization by Modified Steroid Offers a Potential Therapy for Muscular Dystrophy Due to

16 September 18 Articles ، Kanneboyina Nagaraju ، Eric P. Hoffman ، Jack H Vandermeulen LGMD2B ، Vamorolone ، LGMD2B therapy ، Dysferlin deficiency treatment ، Muscle membrane stabilization ، Vamorolone vs Prednisolone ، Steroid treatment for muscular dystrophy ، Dysferlin protein repair ، Clinical trials for LGMD2B ، Muscular Dystrophy
Membrane Stabilization by Modified Steroid Offers a Potential Therapy for Muscular Dystrophy Due to
This study explores the potential of membrane stabilization therapy for LGMD2B using vamorolone, showing it outperforms prednisolone in muscle repair and strength restoration.
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