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Dystrophin Restoration after Adeno-Associated Virus U7eMediated Dmd Exon Skipping Is Modulated by Muscular Exercise in the Severe D2-Mdx Duchenne Muscular Dystrophy Murine Model
This study investigates how voluntary exercise impacts AAV-U7-mediated exon skipping therapy in D2-mdx mice with Duchenne muscular dystrophy (DMD). Exercise did not worsen muscle damage or reduce viral genome expression, though dystrophin-positive muscle area declined from 80% to 65%. Despite this, gene therapy remained effective, and muscle strength improved. Findings suggest exercise can be integrated into DMD treatments without major therapy disruption, though long-term effects need further study.
