Immortalized Skeletal Muscle Cells: Advancing DMD Research    Immortalized skeletal muscle cells derived from both healthy individuals and Duchenne muscular dystrophy (DMD) patients offer a powerful platform for scientific discovery in the field of neuromuscular disorders. These cells provide a reproducible model for studying disease mechanisms and investigating therapeutic strategies, particularly in the context of exon-skipping therapies.     By using these immortalized cells, researchers can explore how …

more

Dystrophin, a crucial protein for maintaining muscle integrity, is severely deficient in Duchenne Muscular Dystrophy (DMD) patients. Quantifying dystrophin restoration following therapeutic interventions is essential for evaluating treatment efficacy. Western blotting, a widely used protein analysis technique, plays a pivotal role in this quantification, with anti-dystrophin antibodies being central to its success.   Anti-dystrophin antibodies are specifically designed to detect and bind dystrophin protein, making them indispensable for Western blot …

more

    Today, on September 7th, we stand together to recognize the relentless fight against Duchenne Muscular Dystrophy. I want to commend all the brilliant researchers, clinicians, and investors who have poured their energy into advancing treatments and finding cures for this challenging condition. Your dedication is making a difference, and I am honored to be a part of this mission. Exactly four years ago, I made a life-changing decision …

more

Personal take on this article: Abstract: This study aimed to evaluate glucose tolerance in adult males with Becker muscular dystrophy (BMD) and Duchenne muscular dystrophy (DMD) using an oral glucose tolerance test (OGTT) and to investigate whether body composition influences glucose response. The study included 28 adults with dystrophinopathy (13 BMD, 15 DMD) and 12 non-dystrophic controls who ingested 75g of glucose. Fingertip blood samples were taken at 30-minute intervals …

more